Moxicip (Moxifloxacin 400mg) 10's

Moxicip general information

What is Moxicip used for?

Moxicip tablets 400mg are used to treat bacterial infections caused by a range of bacteria that have not responded to treatment using other antibiotics. These include respiratory tract infections like bronchitis (acute exacerbations of chronic bronchitis), community acquired pneumonia and acute sinusitis. Moxicip tablets 400mg are also used to treat uncomplicated pelvic inflammatory disease (infections of female upper genital tract, including salpingitis and endometritis). Some infections require intravenous treatment followed by oral treatment with Moxicip tablets 400mg. These include complicated skin and skin structure infections (including diabetic foot infections) and complicated intra-abdominal infections including polymicrobial infections such as abscesses.

How does Moxicip work?

Moxicip tablets 400mg contain moxifloxacin, an antibiotic that belongs to the fluoroquinolone group of antibiotics and is effective against a wide range of susceptible bacteria. Moxifloxacin in Moxicip tablets 400mg acts by inhibiting bacterial topoisomerases. These enzymes are involved in the unwinding of the DNA double helix, which is an important step needed for bacterial DNA replication, by creating breaks in the DNA structure. Once the DNA has been transcribed, repaired or replicated, topoisomerases help connect the DNA back together again allowing it to rewind or recombine into its helical structure. Moxifloxacin in Moxicip tablets 400mg kills the bacteria by preventing bacterial replication and thereby prevents spread of the bacteria. Since the antibacterial mechanism of Moxifloxacin in Moxicip tablets 400mg differs from most other regularly used antibiotics, it can be used for infections where antibiotic resistance causes problems with treatment.

What does Moxicip contain?

Moxicip tablets 400mg contain the active ingredient moxifloxacin hydrochloride, a fluoroquinolone antibiotic used to treat a variety of bacterial infections. They also contain titanium dioxide and red oxide of iron.

Treating bacterial infection with Moxicip

Moxicip tablets 400mg contain moxifloxacin, an antibiotic that belongs to the fluoroquinolone group of antibiotics and is effective against a wide range of infections caused by susceptible bacteria. These include respiratory tract infections like bronchitis (acute exacerbations of chronic bronchitis), community acquired pneumonia and acute sinusitis; also uncomplicated pelvic inflammatory disease (infections of female upper genital tract, including salpingitis and endometritis). Moxicip tablets 400mg are also used to treat complicated skin and skin structure infections (including diabetic foot infections) and complicated intra-abdominal infections including polymicrobial infections such as abscesses that require intravenous treatment followed by oral treatment. Moxifloxacin in Moxicip tablets 400mg acts by inhibiting bacterial topoisomerases, which are enzymes are involved in the unwinding and rewinding of bacterial DNA, an important step needed for bacterial DNA replication, transcription and repair. Moxifloxacin in Moxicip tablets 400mg kills the bacteria by preventing bacterial replication and thereby prevents spread of the bacteria.

What are the side effects of Moxicip?

The most commonly reported side effects when taking Moxicip tablets 400mg include: superinfections (new infection at the same time as the infection being treated) which may be bacterial or fungal, such as oral and vaginal candidiasis (yeast); headache, dizziness, gastrointestinal upset (nausea, vomiting, and abdominal pain, diarrhoea). A more serious but less common side effect is increased risk of tendonitis, which can cause tendon rupture.

When should Moxicip not be used?

You should not use Moxicip tablets 400mg if you:

• are allergic to moxifloxacin or other quinolones or any ingredients in Moxicip
• are pregnant or are breastfeeding
• have kidney or liver disease
• have arrhythmias (abnormal heart rhythm), particularly Q-T prolongation, bradycardia (slow heart beat)
• have low potassium levels
• have seizures
• are taking medicines that interact with Moxicip, including: antiarrhythmics class like quinidine, disopyramide, amiodarone, sotalol, antacids minerals and multi-vitamins, sucralfate, for ulcers, other medicines containing iron, zinc, magnesium, aluminium or calcium, cisapride for reflux, the antibiotic erythromycin, antipsychotics like pimozide, and tricyclic antidepressants, didanosine for viral infections, anticoagulants like warfarin

What medications interact with Moxicip?

Several medications interact with Moxicip and should either not be taken while you are taking Moxicip or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Moxicip: antiarrhythmics class like quinidine, disopyramide, amiodarone, sotalol, cisapride for reflux, the antibiotic erythromycin, antipsychotics like pimozide, tricyclic antidepressants
• Drugs that affect Moxicip: antacids, minerals and multi-vitamins, other medicines containing iron, zinc, magnesium, aluminium or calcium, sucralfate, for ulcers, didanosine for viral infections – these medications must be taken 2-4 hours before taking Moxicip
• Drugs that are affected by Moxicip: anticoagulants like warfarin (coagulation times should be monitored)

How should Moxicip be taken?

You should take your Moxicip tablets 400mg swallowed whole with a glass of water, once daily at the same time each day, with or without food. You should continue to take your Moxicip tablets 400mg for as long as recommended by your doctor. This will depend on what you are being treated for and will be between 5-14 days. You should complete your course of treatment even if you start to feel better.

How long should you take Moxicip?

You should continue to take your Moxicip tablets 400mg for as long as recommended by your doctor, which will be between 5-14 days depending on what you are being treated for and will. You should complete your course of treatment even if you start to feel better.

Missed dose of Moxicip

If you miss a dose of Moxicip tablets 400mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Moxicip be stored?

You should store your Moxicip below 25°C in a cool dry place.