Kenacort-A 10 (by Aspen)

Kenacort-A10 general information

What is Kenacort-A10 used for?

Kenacort-A10 is used to treat pain, swelling and stiffness in a range of inflammatory conditions of joints and tendons, by injecting directly into the painful area of the joint or tendon sheath.  These conditions include osteoarthritis (wear and tear of the joints); rheumatoid arthritis (inflammation and swelling of joints) and acute gouty arthritis (a form of arthritis caused by deposits of uric acid in the joints).  Other painful joint conditions that Kenacort-A10 is used to treat include synovitis and tenosynovitis (inflammation of the synovium or fluid filled sheath that line the ends of joints or that surrounds a tendon); bursitis (inflammation of the fluid-filled sac or bursa between tendon and skin or bone); epicondylitis (also known as tennis elbow due to overuse of the elbow tendon).  Kenacort-A10 injections are also used to treat severe inflammatory skin conditions by injecting under the skin.  These include various forms of dermatitis including lichen planus (chronic itchy rash), granuloma annulare, neurodermatitis (dermatitis causes by chronic itch and scratch cycle), psoriasis (a chronic autoimmune condition causing irritation of the skin with thick red scaly patches); discoid lupus erythematosus (a chronic condition causing sores and inflammation of the face and scalp); also for skin overgrowths such as thickened scar tissue or keloids.  Alopecia areata is thought to be an autoimmune disease where the body attacks the hair follicles leaving small bald patches.  Kenacort-A10 injections into the scalp can help reverse this condition. 

How does Kenacort-A10 work?

Kenacort-A10 contains triamcinalone a synthetic glucocorticoid corticosteroid, similar to the naturally occurring cortisol and its metabolite hydrocortisone, with potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties.  Corticosteroids are hormones that are naturally produced by the adrenal glands and are involved in regulation of many functions including control of inflammatory and immune responses.  Triamcinalone in Kenacort-A10 inhibits the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells at specific sites such as within joint tissue or in skin.  This reduces the swelling, redness and pain associated with inflammation and helps suppress clinical symptoms of a wide range of disorders characterized by excessive inflammation.  These include inflammation in the joints caused by wear and tear in osteoarthritis or overuse as in tennis elbow; also autoimmune diseases, where the immune system is directed against self, as in rheumatoid arthritis or psoriasis; or skin irritation leading to dermatitis.  By injecting Kenacort-A10 locally directly into the site of inflammation it can start to work immediately to provide symptom relief within a few hours. 

What does Kenacort-A10 contain?

Kenacort-A10 ampoules contain an aqueous suspension of the active ingredient triamcinalone acetonide (10mg/mL) a synthetic corticosteroid that is used to treat pain caused by severe inflammation, by injecting into joints, synovium, tendon sheath or under the skin.  Kenacort-A10 suspension also contains sodium chloride, benzyl alcohol, carmellose sodium, polysorbate 80 and water.

Treating inflammation with Kenacort-A10

Kenacort-A10 contains triamcinalone a synthetic corticosteroid that is used to treat a range of conditions characterised by severe inflammation, such as inflammation in the joints caused by wear and tear in osteoarthritis or overuse of the elbow tendon as in epicondylitis (tennis elbow); also autoimmune diseases, where the immune system is directed against self, as in rheumatoid arthritis or psoriasis; or skin irritation leading to dermatitis.  Triamcinalone in Kenacort-A10 inhibits the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells at specific sites such as within joint tissue or in skin to reduce the swelling, redness and pain associated with inflammation.  By injecting Kenacort-A10 locally directly into the site of inflammation it can act on a specific and start work immediately to provide symptom relief within a few hours. 

Kenacort-A10 for joint pain

Kenacort-A10 contains triamcinalone a synthetic corticosteroid that is used to treat joint pain, swelling and stiffness in a range of inflammatory joint conditions, by injecting directly into the painful area of the joint or tendon sheath.  These conditions include osteoarthritis (wear and tear of the joints); rheumatoid arthritis (inflammation and swelling of joints) and acute gouty arthritis (a form of arthritis caused by deposits of uric acid in the joints).  Other painful joint conditions that Kenacort-A10 is used to treat include synovitis and tenosynovitis (inflammation of the synovium or fluid filled sheath that line the ends of joints or that surrounds a tendon); bursitis (inflammation of the fluid-filled sac or bursa between tendon and skin or bone); epicondylitis (also known as tennis elbow due to overuse of the elbow tendon).  Triamcinalone in Kenacort-A10 inhibits the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells at specific sites such as within joint tissue to reduce the swelling, redness and pain associated with inflammation.  By injecting Kenacort-A10 locally directly into the site of inflammation it can act on a specific and start work immediately to provide symptom relief within a few hours. 

Kenacort-A10 for inflammatory skin conditions

Kenacort-A10 contains triamcinalone a synthetic corticosteroid that is used to treat a range of skin conditions characterised by severe inflammation.  These include various forms of dermatitis including lichen planus (chronic itchy rash), granuloma annulare, neurodermatitis (dermatitis causes by chronic itch and scratch cycle), psoriasis (a chronic autoimmune condition causing irritation of the skin with thick red scaly patches); discoid lupus erythematosus (sores and inflammation of the face and scalp); also for skin overgrowths such as thickened scar tissue or keloids.  Triamcinalone in Kenacort-A10 inhibits the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells at specific sites such as within layers of the skin to reduce the swelling, redness, itching and pain associated with inflammation.  By injecting Kenacort-A10 locally directly into the site of inflammation it can act on a specific and start work immediately to provide symptom relief within a few hours.

What are the side effects of Kenacort-A10?

Since Kenacort-A10 is injected locally, general systemic effects are less likely but may still occur.  The most commonly reported side effects when taking Kenacort-A10 include: increased risk and severity of infection, impaired wound healing, high blood pressure, fluid retention, muscle weakness, thinning of the skin, thinning of the bones, with increased risk of fracture, peptic ulcer, convulsions, numbness and tingling, irregular menstrual periods, sore eyes.

When should Kenacort-A10 not be used?

You should not use Kenacort-A10 if you:

• are allergic to triamcinalone or any ingredients in Kenacort-A10 injection
• are pregnant or are breastfeeding
• are due to receive a vaccination with a live virus vaccine as Kenacort-A10 can affect the immune system’s ability to react to the virus
• have no immunity to chicken pox or measles and are at risk of exposure
• have thyroid, stomach, heart, kidney or liver problems, high blood pressure, mood disorders, epilepsy, diabetes, glaucoma, osteoporosis, without discussion with your doctor
• have any infectious disease, including infection in the joint and surrounding tissues
• are diabetic without discussion with your doctor as Kenacort-A10 can increase blood sugar levels
• are taking medicines that interact with Kenacort-A10, including: non-steroidal anti-inflammatories such as; diclofenac and ibuprofen, aspirin, the antifungal amphotericin B, anticholinesterases for myethenia gravis and dementia, Isoniazid for tuberculosis, the immunosuppressant cyclosporine, digoxin for heart failure, oestrogen contraceptives, barbiturate sedatives, the anticonvulsants phenytoin, carbamazepine and primidone, the antibacterial rifampicin, aminoglutethimide for Cushing’s syndrome and adrenal gland disorder, human growth hormone, the antifungal ketoconazole

What medications interact with Kenacort-A10?

Several medications interact with Kenacort-A10 and should either not be taken while you are taking Kenacort-A10 or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction or increased side effects with Kenacort-A10: non-steroidal anti-inflammatories such as; diclofenac and ibuprofen, aspirin, amphotericin B, the immunosuppressant cyclosporine, digoxin for heart failure
• Drugs that affect Kenacort-A10: barbiturate sedatives, the anticonvulsants phenytoin, carbamazepine and primidone, the antibacterial rifampicin, aminoglutethimide for Cushing’s syndrome and adrenal gland disorder
• Drugs that are affected by Kenacort-A10: non-steroidal anti-inflammatories such as; diclofenac and ibuprofen, anticholinesterases for myethenia gravis and dementia, Isoniazid for tuberculosis, the immunosuppressant cyclosporine, digoxin for heart failure, oestrogen contraceptives, human growth hormone, the antifungal ketoconazole,

How should Kenacort-A10 be given?

You will be given an injection of Kenacort-A10 directly into the affected joint or tendon sheath, or under the skin of the skin lesion depending on what you are being treated for.  The dose you receive and how many injections you will be given, depends on your response and should be as recommended by your doctor.  You will usually be given several injections over a period of time but for the shortest time possible to relieve your symptoms to reduce the risk of side effects from long-term treatment.  Your injections will be stopped gradually by reducing the dose.  

How long should you take Kenacort-A10?

You will usually be given several injections over a period of time but for the shortest time possible to relieve your symptoms to reduce the risk of side effects from long-term treatment.  Your injections will be stopped gradually by reducing the dose.  

How should Kenacort-A10 be stored?

You should store your Kenacort-A10 below 30°C in a dark place and must be kept upright and must not be frozen.