Naprosyn SR (Naproxen 1000mg) 28

Naprosyn SR general information

What is Naprosyn SR used for?

Naprosyn SR tablets 1000mg are used to treat chronic inflammatory joint diseases, including osteoarthritis “wear and tear” a chronic degenerative joint disease, where the cartilage around the bone is worn away, most commonly in the hands, feet, hips and spine; rheumatoid arthritis, an autoimmune inflammatory joint disease (where the immune system attacks self), where the lining of the joint (synovium) becomes inflamed and the bone becomes eroded; and ankylosing spondylitis, an autoimmune inflammatory disease that affects the joints in the spine and pelvis and can cause fusion of the spine.  Naprosyn SR tablets 1000mg are also used for musculoskeletal disorders, such as sprains, strains and lower back pain (lumbago) to relieve chronic pain and inflammation.  Naprosyn SR tablets 1000mg do not cure arthritic diseases but can relieve symptoms of pain, inflammation stiffness and swelling and improve the functional use of affected joints.  Naprosyn SR 1000 is not suitable for short-term treatment of acute pain.

How does Naprosyn SR work?

Naprosyn SR tablets 1000mg contain naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory, analgesic (pain relieving) and anti-pyretic properties (reduces fever).  Naproxen in Naprosyn SR tablets 1000mg works by block the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2.  Naproxen in Naprosyn SR tablets 1000mg is a non-selective inhibitor of the enzyme cyclooxygenase (COX) including cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins.  Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness.  Inhibition of COX-1 is responsible for the gastrointestinal side effects that are due to inhibition of protective prostaglandins in the gut and disruption of regulation of acid content.  Naprosyn SR tablets 1000mg are formulated for sustained controlled release, which provides a constant concentration of naproxen over a period of time, for maximum effectiveness and minimum side effects.  

What does Naprosyn SR contain?

Naprosyn SR tablets 1000mg contain the active ingredient naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve joint pain and inflammation in arthritis and other conditions.  They also contain hydroxypropyl methyl cellulose, magnesium stearate, sunset yellow FCF, purified water.

Treating arthritis with Naprosyn SR

Naprosyn tablets 1000mg contain the active ingredient naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation in joints affected with arthritis.  Osteoarthritis (also known as wear and tear and is a degenerative disease) and rheumatoid arthritis (an autoimmune disease where the immune system turns on self) are chronic inflammatory diseases in which the joints become inflamed, swollen and painful.  Naproxen in Naprosyn tablets 1000mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) including cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins.  Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness, to improve the functional use of affected joints. 

Naprosyn SR for pain and inflammation

Naprosyn tablets 1000mg contain naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory, analgesic (pain relieving) and anti-pyretic properties (reduces fever).  Several chronic inflammatory joint diseases cause pain and inflammation, including rheumatoid arthritis (in adults and children), osteoarthritis (wear and tear) and ankylosing spondylitis, (an autoimmune inflammatory disease that affects the joints in the spine and pelvis and can cause fusion of the spine).  Naproxen in Naprosyn tablets 1000mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) including cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins.  Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness.  Naprosyn tablets 1000mg also inhibit cyclooxygenase 1 (COX-1), which is thought to be responsible for the gastrointestinal side effects associated with the non-selective NSAIDs.  Naprosyn tablets 1000mg are formulated for sustained controlled release, which provides a constant concentration of naproxen over a period of time, for maximum effectiveness and minimum side effects, but are not suitable for acute pain. 

What are the side effects of Naprosyn SR?

The most commonly reported side effects when taking Naprosyn SR include upset stomach or stomach pain, diarrhoea, indigestion, bloating wind, heartburn, indigestion, constipation.  Other side effects include: dizziness, drowsiness, headache, light-headedness, vertigo, tinnitus (buzzing or ringing in the ears), oedema and fluid retention, thirst, skin eruptions including rash, itching, sweating.

What are the health risks when taking Naprosyn?

Naprosyn tablets 1000mg have been associated with increased risk of gastric ulceration and bleeding and cardiovascular events including heart attack, although these events are rare.

When should Naprosyn SR not be used?

You should not use Naprosyn SR tablets 1000mg if you:

• are allergic to naproxen or any other NSAID including aspirin or any ingredients in Naprosyn SR
• are pregnant or are breastfeeding, without discussion with your doctor
• have kidney or liver disease
• have aspirin-induced asthma or rhinitis (runny itchy nose)
• have asthma
• have uncontrolled hypertension, severe heart failure or cardiovascular disease, without discussion with your doctor
• have active or a history of gastrointestinal bleeding or perforation due to an ulcer
• have a tendency to bleed easily
• are taking medicines that interact with Naprosyn, including: aspirin or other NSAIDs, anticoagulants like warfarin, cholestyramine for high cholesterol, probenecid for gout, the anti-cancer drug methotrexate, lithium for mood disorders, diuretics like frusemide, beta blockers and ACE inhibitors for high blood pressure, digitalis for heart failure, sulphonamide antibiotics, sulphonylureas for diabetes, SSRI antidepressants, corticosteroids,

What medications interact with Naprosyn SR?

Several medications interact with Naprosyn SR tablets 1000mg and should either not be taken while you are taking Naprosyn SR or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Naprosyn SR: aspirin or other NSAIDs, SSRI antidepressants, anticoagulants like warfarin, and ACE inhibitors
• Drugs that affect Naprosyn SR: cholestyramine for high cholesterol, probenecid for gout
• Drugs that are affected by Naprosyn SR: anticoagulants like warfarin, the anti-cancer drug methotrexate, lithium for mood disorders, diuretics like frusemide, beta blockers and ACE inhibitors for high blood pressure, sulphonamide antibiotics, sulphonylureas for diabetes

How should Naprosyn SR be taken?

You should take your Naprosyn SR tablets 1000mg swallowed whole with a glass of water once daily with or without food, preferably after a meal to reduce risk of gastrointestinal side effects and at the same time each day.  The dose you take and how often depends on what you are being treated for and your doctor’s recommendation.  You should continue to take your Naprosyn SR 1000 for as long as recommended by your doctor, which may be for a few days, several weeks or longer, depending on what you are being treated for, any side effects and how well you respond. 

How long should you take Naprosyn SR?

You should continue to take your Naprosyn tablets 1000mg for as long as recommended by your doctor, which may be for a few days, several weeks or longer, depending on what you are being treated for, any side effects and how well you respond. 

Missed dose of Naprosyn SR

If you miss a dose of Naprosyn SR 1000 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Naprosyn SR be stored?

You should store your Naprosyn SR tablets 1000mg below 25°C in a cool dry place and protect from light.