Domton (Domperidone 10mg) Tablets

Domton general information

What is Domton used for?

Domton tablets 10mg are used to treat acute nausea and vomiting to prevent vomiting and relieve symptoms of nausea. Domton is also used to help relieve symptoms of dyspepsia, like bloating, fullness, heartburn, flatulence and abdominal pain or discomfort when the digestive system is out of rhythm. This can be due to gastroparesis, which is delayed emptying of the stomach caused by slowing down or paralysis of normal muscular muscle contractions as a result of altered eating patterns or some medical conditions; or dysmotility, which is when food processing slows down due to slowing down of the muscular contractions of the small intestine. An off-label use for Domton tablets 10mg is to increase breast milk production.

How does Domton work?

Domton tablets 10mg contain domperidone an antiemetic and prokinetic that is used to relieve symptoms of nausea, vomiting and dyspepsia. Domperidone in Domton tablets 10mg works by blocking receptors for the chemical messenger dopamine in the chemoreceptor trigger zone in the area postrema, which is outside the blood‐brain barrier and is where the vomit response is triggered.

This action of domperidone in Domton stops messages sent from the irritated or upset stomach being received by the chemoreceptor trigger zone, preventing the brain triggering the vomiting response and relieving symptoms of feeling queasy and nauseous. Domton also blocks dopamine receptors in the upper digestive system, which increases contractions of the stomach and intestines, allowing food to move more easily through the stomach.

This action of domperidone in Domton restores the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system. Domton tablets 10mg work through the same mechanism to prevent nausea and vomiting and also to relieve symptoms of dyspepsia and gastroparesis.

What does Domton contain?

Domton tablets 10mg contains the active ingredient domperidone an antiemetic and prokinetic that is used to relieve symptoms of nausea, vomiting and dyspepsia. They also contain the inactive ingredients, starch, lactose, di-calcium phosphate, MCCP 102, titanium dioxide, magnesium stearate and talcum.

Treating nausea, vomiting and dyspepsia with Domton

Domton tablets 10mg contains domperidone an antiemetic and prokinetic that is used to relieve symptoms of acute nausea and vomiting; also, dyspepsia due to gastroparesis, which is delayed emptying of the stomach, or dysmotility, which is when food processing slows down.

Domton relieves symptoms, like bloating, fullness, heartburn, flatulence and abdominal pain or discomfort when the digestive system is out of rhythm. Domperidone in Domton tablets 10mg works by blocking receptors for the chemical messenger dopamine in the chemoreceptor trigger zone, the area of the brain that triggers the vomiting response, which prevents messages sent from the irritated or upset stomach being received by the chemoreceptor trigger zone and relieving symptoms of feeling queasy and nauseous and preventing vomiting.

Domperidone in Domton also blocks dopamine receptors in the upper digestive system, which increases contractions of the stomach and intestines, allowing food to move more easily through the stomach. This action of domperidone in Domton restores the natural rhythm of muscle contraction and relaxation in the stomach and intestines, which helps push food through the digestive system and relieves symptoms of nausea and dyspepsia.

Domton for increasing breast milk production

Domton tablets 10mg contains domperidone an antiemetic and prokinetic that can also be used to increase breast milk production as a side effect of its actions, for women who are having trouble producing enough breast milk. Domperidone in Domton tablets 10mg increases blood levels of the hormone prolactin, which stimulates milk production in a new mother's breast cells.

This is an indirect result of blocking the action of the chemical messenger dopamine, which is also how Domton prevents nausea and vomiting. Domton does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm the baby.

Domperidone in Domton tablets 10mg has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

What are the side effects of Domton?

The most commonly reported side effects when taking Domton tablets 10mg include headache, abdominal cramps, and dry mouth. Because domperidone in Domton tablets 10mg does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications.

However, for the same reason Domton can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea). These side effects are temporary will stop as soon as you stop taking Domton.

When should Domton not be used?

You should not use Domton tablets 10mg if you:

• are allergic to domperidone or any ingredients in Domton
• are pregnant or are breastfeeding, without discussion with your doctor
• have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used in the tablet manufacturing process.
• have kidney or liver disease
• have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction, or a perforation
• have certain heart conditions
• have a pituitary tumour that causes over-production of prolactin (prolactinoma).
• are taking medicines that interact with Domton including the antifungals ketoconazole, fluconazole or voriconazole, antibiotics containing erythromycin, clarithromycin or telithromycin, the antiarrhythmic amiodarone, ritonavir, saquinavir, telaprevir for HIV, anti-arrhythmics like disopyramide and amiodarone, antipsychotics like pimozide, antidepressants like citalopram, antibiotics like erythromycin, gastro-intestinal medicines like cisapride, opioids like methadone.

Interactions with Domton?

Several medications interact with Domton tablets 10mg and should either not be taken while you are taking Domton or only after discussion and instruction from your doctor:

• Drugs that may cause a serious reaction with Domton: anti-arrhythmics like disopyramide and amiodarone, antipsychotics like pimozide, antidepressants like citalopram, gastro-intestinal medicines like cisapride, opioids like methadone,
• Drugs that affect Domton: the antifungal ketoconazole, fluconazole or voriconazole, antibiotic containing erythromycin, clarithromycin or telithromycin, the antiarrhythmic amiodarone, ritonavir, saquinavir, telaprevir for HIV, anti-arrhythmics like disopyramide and amiodarone, antipsychotics like pimozide, antidepressants like citalopram, antibiotics like erythromycin, gastro-intestinal medicines like cisapride, opioids like methadone.

How should Domton be taken?

You should take Domton tablets 10mg swallowed whole with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime, if necessary.

To increase breastmilk the usual dosage recommended by lactation consultants is up to TWO tablets FOUR times a day.

The dose you take and for how long depends on what you are being treated for and your doctor's recommendation.

How long should you take Domton?

Domton tablets 10mg is not intended for long-term use and you should not continue to take your Domton tablets 10mg for more than two weeks, unless recommended by your doctor.

Missed dose of Domton tablets?

If you miss a dose of Domton tablets 10mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Domton be stored?

You should store your Domton tablets 10mg below 25°C in a cool dry place, well out of reach of children.